May 2006

• High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol

  Michael Bandell, Adrienne E Dubin, Matt J Petrus, Anthony Orth, Jayanti Mathur, Sun Wook Hwang & Ardem Patapoutian
  Nature Neuroscience 9 493 - 500
  (5 March 2006); doi:10.1038/nn1665

  Abstract

• A mint of mutations in TRPM8 leads to cool results

  Standfirst

  Both menthol and cool temperatures activate the cation channel TRPM8, but whether they do so via distinct domains was unclear. A new paper shows that activation of TRPM8 by these two stimuli can be separated.

  Craig Montell
  Nature Neuroscience 9 466 - 468
  doi:10.1038/nn0406-466

  Abstract

• ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

  Matthew J Greenway, Peter M Andersen, Carsten Russ, Sean Ennis, Susan Cashman, Colette Donaghy, Victor Patterson, Robert Swingler, Dairin Kieran, Jochen Prehn, Karen E Morrison, Andrew Green, K Ravi Acharya, Robert H Brown, Jr & Orla Hardiman
  Nature Genetics 38 411 - 413
  (26 February 2006); doi:10.1038/ng1742

  Abstract

• Luminescent imaging of -galactosidase activity in living subjects using sequential reporter-enzyme luminescence

  Thomas S Wehrman, Georges Von degenfeld, Peter O Krutzik, Garry P Nolan & Helen M Blau
  Nature Methods 3 295 - 301
  (22 March 2006); doi:10.1038/nmeth868

  Abstract

• Synphilin-1A: An aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from  -synucleinopathy patients

  A. Eyal
  Proceedings of the National Academy of Sciences 103
  (11 April 2006); doi:10.1073/pnas.0509707103

  Abstract

• An isochore map of human chromosomes

  M. Costantini
  Genome Research 16
  (13 March 2006); doi:10.1101/gr.4910606

  Abstract

• Umar Yazdani & Jonathan R Terman
  Genome Biology 7
  (1 January 2006); doi:10.1186/gb-2006-7-3-211

  Abstract

• Requirement of Akt to Mediate Long-Term Synaptic Depression in Drosophila

  H.-F. Guo
  Journal of Neuroscience 26
  (12 April 2006); doi:10.1523/JNEUROSCI.3616-05.2006

  Abstract

• Opioid Receptors in the Nucleus Accumbens Regulate Attentional Learning in the Blocking Paradigm

  M. D. Iordanova
  Journal of Neuroscience 26
  (12 April 2006); doi:10.1523/JNEUROSCI.4679-05.2006

  Abstract

• Impaired Sequential Egocentric and Allocentric Memories in Forebrain-Specific-NMDA Receptor Knock-Out Mice during a New Task Dissociating Strategies of Navigation

  L. Rondi-reig
  Journal of Neuroscience 26
  (12 April 2006); doi:10.1523/JNEUROSCI.3408-05.2006

  Abstract

• Somatosensory Cells in Area PEc of Macaque Posterior Parietal Cortex

  R. Breveglieri
  Journal of Neuroscience 26
  (5 April 2006); doi:10.1523/JNEUROSCI.4637-05.2006

  Abstract

• Towards the integration of spatially and temporally resolved murine gene expression databases

  S Sunkin
  Trends in Genetics 22
  (1 April 2006); doi:10.1016/j.tig.2006.02.006

  Abstract

• Differences between pair-wise and multi-sequence alignment methods affect vertebrate genome comparisons

  E Margulies, C Chen & E Green
  Trends in Genetics 22
  (1 April 2006); doi:10.1016/j.tig.2006.02.005

  Abstract

• Role of matrix metalloproteinases in delayed cortical responses after stroke

  Bing-Qiao Zhao, Sophia Wang, Hahn-Young Kim, Hannah Storrie, Bruce R Rosen, David J Mooney, Xiaoying Wang & Eng H Lo
  Nature Medicine 12 441 - 445
  (26 March 2006); doi:10.1038/nm1387

  Abstract

• Remodeling after stroke

  Standfirst

  A promising approach to treating ischemic stroke, inhibition of matrix metalloproteinases (MMPs), may need to be rethought. Previous work suggested that inhibitors of MMPs could protect the brain, but now it seems that such inhibitors might contribute to damage (pages 441–445).

  Berislav V Zlokovic
  Nature Medicine 12 390 - 391
  doi:10.1038/nm0406-390

  Abstract

• Putting pharmacogenetics into practice

  Standfirst

  Genetics is slowly explaining variations in drug response, but applying this knowledge depends on implementation of a host of policies that provide long-term support to the field, from translational research and regulation to professional education.

  Michael M Hopkins, Dolores Ibarreta, Sibylle Gaisser, Christien M Enzing, Jim Ryan, Paul A Martin, Graham Lewis, Symone Detmar, M Elske Van den akker-van marle, Adam M Hedgecoe, Paul Nightingale, Marieke Dreiling, K Juliane Hartig, Wieneke Vullings & Tony Forde
  Nature Biotechnology 24 403 - 410
  doi:10.1038/nbt0406-403

  Abstract

• Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes

  Michael F Waters, Natali A Minassian, Giovanni Stevanin, Karla P Figueroa, John P A Bannister, Dagmar Nolte, Allan F Mock, Virgilio Gerald H Evidente, Dominic B Fee, Ulrich Müller, Alexandra Dürr, Alexis Brice, Diane M Papazian & Stefan M Pulst
  Nature Genetics 38 447 - 451
  (26 February 2006); doi:10.1038/ng1758

  Abstract

• Additive Effects of Genetic Variation in Dopamine Regulating Genes on Working Memory Cortical Activity in Human Brain

  A. Bertolino
  Journal of Neuroscience 26
  (12 April 2006); doi:10.1523/JNEUROSCI.4975-05.2006

  Abstract