Research library: browse by date
The Research Library categorizes and alerts you to recent neuroscience- and genomics-related research in journals from the Nature family and from other publishers. Primary research and review articles are included, as are News and Views.
June 2006
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazar & Mark A. Kay
Nature 441 537 - 541
doi:10.1038/nature04791Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory
E. Palma
Proceedings of the National Academy of Sciences 103
(30 May 2006); doi:10.1073/pnas.0602979103From the Cover: PKC increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
D.-S. Choi
Proceedings of the National Academy of Sciences 103
(15 May 2006); doi:10.1073/pnas.0509725103A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons
A. M. Rush
Proceedings of the National Academy of Sciences 103
(15 May 2006); doi:10.1073/pnas.0602813103Gas6/Axl Signaling Activates the Phosphatidylinositol 3-Kinase/Akt1 Survival Pathway to Protect Oligodendrocytes from Tumor Necrosis Factor -Induced Apoptosis
S. L. Shankar
Journal of Neuroscience 26
(24 May 2006); doi:10.1523/JNEUROSCI.5063-05.2006Motor Axon Guidance of the Mammalian Trochlear and Phrenic Nerves: Dependence on the Netrin Receptor Unc5c and Modifier Loci
R. W. Burgess
Journal of Neuroscience 26
(24 May 2006); doi:10.1523/JNEUROSCI.0736-06.2006The Wnt Receptor Ryk Is Required for Wnt5a-Mediated Axon Guidance on the Contralateral Side of the Corpus Callosum
T. R. Keeble
Journal of Neuroscience 26
(24 May 2006); doi:10.1523/JNEUROSCI.1175-06.2006Transient Suppression of Ipsilateral Primary Somatosensory Cortex during Tactile Finger Stimulation
Y. Hlushchuk
Journal of Neuroscience 26
(24 May 2006); doi:10.1523/JNEUROSCI.5536-05.2006Genes Associated with Adult Axon Regeneration Promoted by Olfactory Ensheathing Cells: A New Role for Matrix Metalloproteinase 2
E. Pastrana
Journal of Neuroscience 26
(17 May 2006); doi:10.1523/JNEUROSCI.1111-06.2006Necdin Promotes GABAergic Neuron Differentiation in Cooperation with Dlx Homeodomain Proteins
T. Kuwajima
Journal of Neuroscience 26
(17 May 2006); doi:10.1523/JNEUROSCI.1262-06.2006Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses
I. Katona
Journal of Neuroscience 26
(24 May 2006); doi:10.1523/JNEUROSCI.0309-06.2006WAVE1 Is Required for Oligodendrocyte Morphogenesis and Normal CNS Myelination
H.-J. Kim
Journal of Neuroscience 26
(24 May 2006); doi:10.1523/JNEUROSCI.4921-05.2006A Role for Nr-CAM in the Patterning of Binocular Visual Pathways
S Williams, M Grumet, D Colman, M Henkemeyer, C Mason & T Sakurai
Neuron 50
(18 May 2006); doi:10.1016/j.neuron.2006.03.037Cell Survival through Trk Neurotrophin Receptors Is Differentially Regulated by Ubiquitination
J Arevalo, J Waite, R Rajagopal, M Beyna, Z Chen, F Lee & M Chao
Neuron 50
(18 May 2006); doi:10.1016/j.neuron.2006.03.044Modulation of Basal and Receptor-Induced GIRK Potassium Channel Activity and Neuronal Excitability by the Mammalian PINS Homolog LGN
O Wiser, X Qian, M Ehlers, W Ja, R Roberts, E Reuveny, Y Jan & L Jan
Neuron 50
(18 May 2006); doi:10.1016/j.neuron.2006.03.046Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants
R Vigot, S Barbieri, H Braunerosborne, R Turecek, R Shigemoto, Y Zhang, R Lujan, L Jacobson, B Biermann & J Fritschy
Neuron 50
(18 May 2006); doi:10.1016/j.neuron.2006.04.014The GABAB1b Isoform Mediates Long-Lasting Inhibition of Dendritic Ca2+ Spikes in Layer 5 Somatosensory Pyramidal Neurons
E Perezgarci, M Gassmann, B Bettler & M Larkum
Neuron 50
(18 May 2006); doi:10.1016/j.neuron.2006.04.019Anterior Cingulate and Posterior Parietal Cortices Are Sensitive to Dissociable Forms of Conflict in a Task-Switching Paradigm
C Liston, S Matalon, T Hare, M Davidson & B Casey
Neuron 50
(18 May 2006); doi:10.1016/j.neuron.2006.04.015Miniature Neurotransmission Stabilizes Synaptic Function via Tonic Suppression of Local Dendritic Protein Synthesis
M Sutton, H Ito, P Cressy, C Kempf, J Woo & E Schuman
Cell 125
(19 May 2006); doi:10.1016/j.cell.2006.03.040Evaluating coverage of genome-wide association studies
Jeffrey C Barrett & Lon R Cardon
Nature Genetics 38 659 - 662
(21 May 2006); doi:10.1038/ng1801Evaluating and improving power in whole-genome association studies using fixed marker sets
Itsik Pe'er, Paul I W De bakker, Julian Maller, Roman Yelensky, David Altshuler & Mark J Daly
Nature Genetics 38 663 - 667
(21 May 2006); doi:10.1038/ng1816Agnosticism and equity in genome-wide association studies
Standfirst
Two new studies evaluate the extent to which widely used SNP platforms capture common variation in different populations, and they present strategies for improving power in whole-genome association studies using fixed marker sets. Their results suggest that genome-wide association studies are finally ready to move from theory to practice.
Christopher S Carlson
Nature Genetics 38 605 - 606
doi:10.1038/ng0606-605The Jewels of Our Genome: The Search for the Genomic Changes Underlying the Evolutionarily Unique Capacities of the Human Brain
James M. Sikela
PLoS Genetics 2
(1 January 2006); doi:10.1371/journal.pgen.0020080Adrienne E Mckee & Pamela A Silver
Genome Biology 7
(1 January 2006); doi:10.1186/gb-2006-7-5-316Douglas L Black & Brenton R Graveley
Genome Biology 7
(1 January 2006); doi:10.1186/gb-2006-7-5-317Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons
Rumiko Mizuguchi, Sonja Kriks, Ralf Cordes, Achim Gossler, Qiufu Ma & Martyn Goulding
Nature Neuroscience 9
(21 June 2006); doi:10.1038/nn1706Impaired light masking in dopamine D2 receptor–null mice
Masao Doi, Irene Yujnovsky, Jun Hirayama, Monica Malerba, Emanuele Tirotta, Paolo Sassone-corsi & Emiliana Borrelli
Nature Neuroscience 9
(21 June 2006); doi:10.1038/nn1711BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
Jeffrey A Kleim, Sheila Chan, Erin Pringle, Kellan Schallert, Vincent Procaccio, Richard Jimenez & Steven C Cramer
Nature Neuroscience 9
(7 June 2006); doi:10.1038/nn1699Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized
Thierry Bienvenu & Jamel Chelly
Nature Reviews Genetics 7 415 - 426
doi:10.1038/nrg1878Genetics: What is a gene?
Standfirst
The idea of genes as beads on a DNA string is fast fading. Protein-coding sequences have no clear beginning or end and RNA is a key part of the information package, reports Helen Pearson.
Helen Pearson
Nature 441 398 - 401
(24 May 2006); doi:10.1038/441398aOnset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
S. Boillee
Science 312
(2 June 2006); doi:10.1126/science.1123511Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
Thiruma V Arumugam, Sic L Chan, Dong-Gyu Jo, Gokhan Yilmaz, Sung-Chun Tang, Aiwu Cheng, Marc Gleichmann, Eitan Okun, Vishwa D Dixit, Srinivasulu Chigurupati, Mohamed R Mughal, Xin Ouyang, Lucio Miele, Tim Magnus, Suresh Poosala, D Neil Granger & Mark P Mattson
Nature Medicine 12 621 - 623
(7 May 2006); doi:10.1038/nm1403Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain
Hiroyuki Koizumi, Holden Higginbotham, Tiffany Poon, Teruyuki Tanaka, Brendan C Brinkman & Joseph G Gleeson
Nature Neuroscience 9
(14 June 2006); doi:10.1038/nn1704Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O
Takafumi Shintani, Masaru Ihara, Hiraki Sakuta, Hiroo Takahashi, Ikuko Watakabe & Masaharu Noda
Nature Neuroscience 9
(7 June 2006); doi:10.1038/nn1697RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion
Jun Ding, Jaime N Guzman, Tatiana Tkatch, Songhai Chen, Joshua A Goldberg, Philip J Ebert, Pat Levitt, Charles J Wilson, Heidi E Hamm & D James Surmeier
Nature Neuroscience 9
(14 June 2006); doi:10.1038/nn1700Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
Yuqin Yin, Michael T Henzl, Barbara Lorber, Toru Nakazawa, Tommy T Thomas, Fan Jiang, Robert Langer & Larry I Benowitz
Nature Neuroscience 9
(14 June 2006); doi:10.1038/nn1701A dynamic role for the mushroom bodies in promoting sleep in Drosophila
Jena L. Pitman, Jermaine J. Mcgill, Kevin P. Keegan & Ravi Allada
Nature 441 753 - 756
doi:10.1038/nature04739Sleep in Drosophila is regulated by adult mushroom bodies
William J. Joiner, Amanda Crocker, Benjamin H. White & Amita Sehgal
Nature 441 757 - 760
doi:10.1038/nature04811Mutations in CEP290, which encodes a centrosomal protein, cause pleiotropic forms of Joubert syndrome
Enza Maria Valente, Jennifer L Silhavy, Francesco Brancati, Giuseppe Barrano, Suguna Rani Krishnaswami, Marco Castori, Madeline A Lancaster, Eugen Boltshauser, Loredana Boccone, Lihadh Al-gazali, Elisa Fazzi, Sabrina Signorini, Carrie M Louie, Emanuele Bellacchio, International Joubert Syndrome Related disorders study group, Enrico Bertini, Bruno Dallapiccola & Joseph G Gleeson
Nature Genetics 38 623 - 625
(7 May 2006); doi:10.1038/ng1805The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
John A Sayer, Edgar A Otto, John F O'toole, Gudrun Nurnberg, Michael A Kennedy, Christian Becker, Hans Christian Hennies, Juliana Helou, Massimo Attanasio, Blake V Fausett, Boris Utsch, Hemant Khanna, Yan Liu, Iain Drummond, Isao Kawakami, Takehiro Kusakabe, Motoyuki Tsuda, Li Ma, Hwankyu Lee, Ronald G Larson, Susan J Allen, Christopher J Wilkinson, Erich A Nigg, Chengchao Shou, Concepcion Lillo, David S Williams, Bernd Hoppe, Markus J Kemper, Thomas Neuhaus, Melissa A Parisi, Ian A Glass, Marianne Petry, Andreas Kispert, Joachim Gloy, Athina Ganner, Gerd Walz, Xueliang Zhu, Daniel Goldman, Peter Nurnberg, Anand Swaroop, Michel R Leroux & Friedhelm Hildebrandt
Nature Genetics 38 674 - 681
(7 May 2006); doi:10.1038/ng1786GENETICS: DNA's Molecular Gymnastics
E. Pennisi
Science 312
(9 June 2006); doi:10.1126/science.312.5779.1467MOLECULAR BIOLOGY: Genes Commute to Factories Before They Start Work
E. Pennisi
Science 312
(2 June 2006); doi:10.1126/science.312.5778.1304HUMAN GENETICS: Finding Criminals Through DNA of Their Relatives
F. R. Bieber
Science 312
(2 June 2006); doi:10.1126/science.1122655Coverage and Characteristics of the Affymetrix GeneChip Human Mapping 100K SNP Set
Dan L. Nicolae, Xiaoquan Wen, Benjamin F. Voight & Nancy J. Cox
PLoS Genetics 2
(1 January 2006); doi:10.1371/journal.pgen.0020067Environmental Enrichment Enhances Neurogranin Expression and Hippocampal Learning and Memory But Fails to Rescue the Impairments of Neurogranin Null Mutant Mice
F. L. Huang
Journal of Neuroscience 26
(7 June 2006); doi:10.1523/JNEUROSCI.1182-06.2006Lithium Administration to Preadolescent Rats Causes Long-Lasting Increases in Anxiety-Like Behavior and Has Molecular Consequences
R. M. Youngs
Journal of Neuroscience 26
(31 May 2006); doi:10.1523/JNEUROSCI.0580-06.2006Regulation of Intracellular Trafficking of Huntingtin-Associated Protein-1 Is Critical for TrkA Protein Levels and Neurite Outgrowth
J. Rong
Journal of Neuroscience 26
(31 May 2006); doi:10.1523/JNEUROSCI.1251-06.2006Midline radial glia translocation and corpus callosum formation require FGF signaling
Karen Müller Smith, Yasushi Ohkubo, Maria Elisabetta Maragnoli, Mladen-Roko Rašin, Michael L Schwartz, Nenad Šestan & Flora M Vaccarino
Nature Neuroscience 9
(21 June 2006); doi:10.1038/nn1705Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice
Robert A. Koza, Larissa Nikonova, Jessica Hogan, Jong-Seop Rim, Tamra Mendoza, Christopher Faulk, Jihad Skaf & Leslie P. Kozak
PLoS Genetics 2
(1 January 2006); doi:10.1371/journal.pgen.0020081Microtargeted Gene Silencing and Ectopic Expression in Live Embryos Using Biolistic Delivery with a Pneumatic Capillary Gun
O. Shefi
Journal of Neuroscience 26
(7 June 2006); doi:10.1523/JNEUROSCI.1237-06.2006Cortical substrates for exploratory decisions in humans
Nathaniel D. Daw, John P. O'doherty, Peter Dayan, Ben Seymour & Raymond J. Dolan
Nature 441 876 - 879
doi:10.1038/nature04766Protein therapeutics: new applications for pharmacogenetics
Cecile Krejsa, Mark Rogge & Wolfgang Sadee
Nature Reviews Drug Discovery 5 507 - 521
doi:10.1038/nrd2039An epigenetic state associated with areas of gene duplication
A. A. Gimelbrant
Genome Research 16
(1 June 2006); doi:10.1101/gr.5023706Genome-wide analysis of mammalian promoter architecture and evolution
Piero Carninci, Albin Sandelin, Boris Lenhard, Shintaro Katayama, Kazuro Shimokawa, Jasmina Ponjavic, Colin A M Semple, Martin S Taylor, Pär G Engström, Martin C Frith, Alistair R R Forrest, Wynand B Alkema, Sin Lam Tan, Charles Plessy, Rimantas Kodzius, Timothy Ravasi, Takeya Kasukawa, Shiro Fukuda, Mutsumi Kanamori-katayama, Yayoi Kitazume, Hideya Kawaji, Chikatoshi Kai, Mari Nakamura, Hideaki Konno, Kenji Nakano, Salim Mottagui-tabar, Peter Arner, Alessandra Chesi, Stefano Gustincich, Francesca Persichetti, Harukazu Suzuki, Sean M Grimmond, Christine A Wells, Valerio Orlando, Claes Wahlestedt, Edison T Liu, Matthias Harbers, Jun Kawai, Vladimir B Bajic, David A Hume & Yoshihide Hayashizaki
Nature Genetics 38 626 - 635
(28 April 2006); doi:10.1038/ng1789Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease
J. L. Mcbride
Proceedings of the National Academy of Sciences 103
(1 June 2006); doi:10.1073/pnas.0508875103Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity
S. L. Zhang
Proceedings of the National Academy of Sciences 103
(1 June 2006); doi:10.1073/pnas.0603161103Neuronal Pentraxins Mediate Synaptic Refinement in the Developing Visual System
L. Bjartmar
Journal of Neuroscience 26
(7 June 2006); doi:10.1523/JNEUROSCI.4212-05.2006A Role for 1 Tubulin-Expressing Muller Glia in Regeneration of the Injured Zebrafish Retina
B. V. Fausett
Journal of Neuroscience 26
(7 June 2006); doi:10.1523/JNEUROSCI.0332-06.2006