July 2007

• Alternative splicing switches on the brain

  Standfirst

  An alternative splicing repressor blocks the expression of its brain-specific paralog in non-neural cells.

  Patrick Goymer
  Nature Reviews Genetics 8 572
  (3 July 2007); doi:10.1038/nrg2162

• New avenues for stroke treatment

  Standfirst

  Histone deacetylase inhibitors reduce ischemia-mediated inflammation and apoptosis.

  Charlotte Harrison
  Nature Reviews Drug Discovery 6 520
  doi:10.1038/nrd2364

• Specifically attenuating pain

  Standfirst

  An inhibitor to Na_v1.8 blocks pain in several rat models.

  Monica Hoyos Flight
  Nature Reviews Drug Discovery 6 518 - 519
  doi:10.1038/nrd2365

• Containing the excitement

  Standfirst

  Reductions in tau limit Aβ-induced cognitive decline by preventing excitotoxicity.

  Monica Hoyos flight
  Nature Reviews Neuroscience 8 492 - 493
  doi:10.1038/nrn2173

• An aid to digestion

  Standfirst

  High throughput screens identify small molecules that enhance autophagy and help clear aggregates of proteins involved in neurodegeneration.

  Sarah Crunkhorn
  Nature Reviews Drug Discovery 6 518
  doi:10.1038/nrd2362

• Directing traffic

  Standfirst

  Glutamate increases sumoylation of a kainate receptor subunit, which induces receptor internalization.

  Katherine Whalley
  Nature Reviews Neuroscience 8 492 - 493
  doi:10.1038/nrn2172

• A long and lean life

  Standfirst

  Two neurons and one transcription factor are important in the caloric restriction-induced increase in longevity in C. elegans.

  Leonie Welberg
  Nature Reviews Neuroscience 8 494 - 495
  doi:10.1038/nrn2177

• Exploring profilin

  Standfirst

  Profilin 2 regulates synaptic vesicle release.

  Claudia Wiedemann
  Nature Reviews Neuroscience 8 494 - 495
  doi:10.1038/nrn2182