November 2007

• Gene therapy: Gene editors deliver

  Standfirst

  To avoid random insertion, new gene therapy agents use site-specific DNA nucleases.

  Louisa Flintoft
  Nature Reviews Genetics 8 908 - 909
  doi:10.1038/nrg2277

• Epigenetics: Methylation and schizophrenia

  Standfirst

  Maturation increases and schizophrenia decreases the methylation of histones associated with genes that are involved in GABA production.

  Monica Hoyos Flight
  Nature Reviews Neuroscience 8 910 - 911
  doi:10.1038/nrn2282

• Antipsychotics: An emerging alternative

  Standfirst

  A metabotropic glutamate receptor agonist improves symptoms of schizophrenia.

  Monica Hoyos Flight
  Nature Reviews Drug Discovery 6 870
  doi:10.1038/nrd2452

• Molecular neurobiology: Chained together

  Standfirst

  Dynamin-3 and Homer physically link the endocytic zone to the postsynaptic density and are important in recycling neurotransmitter receptors.

  Claudia Wiedemann
  Nature Reviews Neuroscience 8 814 - 815
  doi:10.1038/nrn2270

• Gene expression in the worm

  Standfirst

  Large-scale analysis of gene expression in the nematode Caenorhabditis elegans takes advantage of its transparency and completely described cellular lineage.

  Natalie de Souza
  Nature Methods 4 884
  doi:10.1038/nmeth1107-884

• Affective disorders: Less SAD with more sun and serotonin

  Standfirst

  People with seasonal affective disorder show increased rates of serotonin transport that normalize following bright-light therapy.

  Leonie Welberg
  Nature Reviews Neuroscience 8 812
  doi:10.1038/nrn2263

• Gene regulation: The many paths to coexpression

  Standfirst

  Cis-regulatory elements that drive tissue-specific expression are highly variable.

  Louisa Flintoft
  Nature Reviews Genetics 8 827
  doi:10.1038/nrg2228

• Ion channels: Spicing up local anaesthetics

  Standfirst

  Together, anesthetic treatment and capsaicin block pain without affecting other sensations.

  Katherine Whalley
  Nature Reviews Neuroscience 8 811
  doi:10.1038/nrn2265