January 2008

• G-protein-coupled receptors: Crystal clear

  Several research groups describe the structure of β2-adrenergic receptors, the second G-protein-coupled receptor to be crystallized.

  Charlotte Harrison
  Nature Reviews Drug Discovery 7 19
  doi:10.1038/nrd2493

• Neurodegenerative disorders: ASIC mind

  Acid-sensitive ion channel 1 is involved in the pathophysiology of multiple sclerosis.

  Craig Nicholson
  Nature Reviews Neuroscience 9 6
  doi:10.1038/nrn2302

• Neurotransmission: Getting vesicles ready for action

  CAPS proteins are important in the priming of synaptic vesicles for release.

  Katherine Whalley
  Nature Reviews Neuroscience 9 9
  doi:10.1038/nrn2304

• Memory: The dual path to recognition

  The neural correlates for recognition and familiarity are distinct.

  Claudia Wiedemann
  Nature Reviews Neuroscience 9 8
  doi:10.1038/nrn2312

• Gene regulation: One cell, one smell

  Standfirst

  The factor that suppresses the expression of all olfactory receptor genes but one in each olfactory receptor cell is encoded in the gene itself.

  Tanita Casci
  Nature Reviews Genetics 9 4 - 5
  doi:10.1038/nrg2300

• Neurogenesis: Par for the course

  Standfirst

  The polarity markers partitioning-defective-complex proteins maintain the proliferative potential of ventricular zone progenitor cells.

  Craig Nicholson
  Nature Reviews Neuroscience 9 7
  doi:10.1038/nrn2308

• Metabolic disease: New opportunity for serotonin receptor agonists

  Standfirst

  Serotonin 2C receptor agonists may benefit people with type 2 diabetes.

  Sarah Crunkhorn
  Nature Reviews Drug Discovery 7 17
  doi:10.1038/nrd2492

• Psychiatric disorders: Digging deeper into epigenetic regulation

  Standfirst

  Histone deacetylase 5 is important in chronic stress and drug-seeking behaviors.

  Katherine Whalley
  Nature Reviews Neuroscience 9 6
  doi:10.1038/nrn2299