February 2008

• Chemogenomics: A change of tactic

  Standfirst

  Researchers use binding-site homologies and structure-activity relationships to design a somatostatin receptor antagonist.

  Monica Hoyos Flight
  Nature Reviews Drug Discovery 7 122
  doi:10.1038/nrd2521

• Behaviour: Mating games

  Standfirst

  Two studies address the molecular mechanisms of mating behaviors in Drosophila.

  Craig Nicholson
  Nature Reviews Neuroscience 9 80 - 81
  doi:10.1038/nrn2316

• Synaptic plasticity: Learning through continuing potentiation

  Standfirst

  Extended periods of synaptic plasticity involve activation of both NMDA and metabotropic glutamate receptors.

  Leonie Welberg
  Nature Reviews Neuroscience 9 82 - 83
  doi:10.1038/nrn2321

• Sensory perception: One TRPM8 fits all

  Standfirst

  TRPM8 mediates different cold sensations in different sensory neurons.

  Leonie Welberg
  Nature Reviews Neuroscience 9 79
  doi:10.1038/nrn2323

• Gathering a bouquet of miRNA targets

  Standfirst

  Pulling down microRNA-induced silencing complexes (miRISCs) allows researchers to collect microRNAs and their mRNA targets in vivo.

  Katherine Stevens
  Nature Methods 5 122 - 123
  doi:10.1038/nmeth0208-122b

• Protein homeostasis: External influence

  Standfirst

  Defective neurotransmitter signaling disrupts protein homeostasis.

  Monica Hoyos Flight
  Nature Reviews Neuroscience 9 84
  doi:10.1038/nrn2319

• Neurological disorders: A fragile balance

  Standfirst

  Metabotropic glutamate receptor inhibitors may be beneficial for people with fragile X syndrome.

  Katherine Whalley
  Nature Reviews Neuroscience 9 79
  doi:10.1038/nrn2324

• Neural coding: The power of one

  Standfirst

  A single action potential in a single neuron can induce a behavioral response.

  Katherine Whalley
  Nature Reviews Neuroscience 9 78
  doi:10.1038/nrn2329