Cell signaling

• Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions

  S. Pezet, F. Marchand, R. D'Mello, J. Grist, A. K. Clark, M. Malcangio, A. H. Dickenson, R. J. Williams & S. B. McMahon
  Journal of Neuroscience 28
  (16 April 2008); doi:10.1523/JNEUROSCI.5392-07.2008

  Abstract

• Neurturin-Mediated Ret Activation Is Required for Retinal Function

  M. A. Brantley, S. Jain, E. E. Barr, E. M. Johnson & J. Milbrandt
  Journal of Neuroscience 28
  (16 April 2008); doi:10.1523/JNEUROSCI.0249-08.2008

  Abstract

• Regulation of Motor Neuron Specification by Phosphorylation of Neurogenin 2

  Y Ma, M Song, J Park, H Henryho, L Hu, M Kurtev, J Zieg, Q Ma, S Pfaff & M Greenberg
  Neuron 58
  (10 April 2008); doi:10.1016/j.neuron.2008.01.037

  Abstract

• TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation

  Megumi Kaneko, Jessica L Hanover, Pamela M England & Michael P Stryker
  Nature Neuroscience 11 497 - 504
  (2 March 2008); doi:10.1038/nn2068

  Abstract

• Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

  Sofia Papadia, Francesc X Soriano, Frédéric Léveillé, Marc-Andre Martel, Kelly A Dakin, Henrik H Hansen, Angela Kaindl, Marco Sifringer, Jill Fowler, Vanya Stefovska, Grahame Mckenzie, Marie Craigon, Roderick Corriveau, Peter Ghazal, Karen Horsburgh, Bruce A Yankner, David J A Wyllie, Chrysanthy Ikonomidou & Giles E Hardingham
  Nature Neuroscience 11 476 - 487
  (23 March 2008); doi:10.1038/nn2071

  Abstract

• Segregation of Axial Motor and Sensory Pathways via Heterotypic Trans-Axonal Signaling

  B. W. Gallarda, D. Bonanomi, D. Müller, A. Brown, W. A. Alaynick, S. E. Andrews, G. Lemke, S. L. Pfaff & T. Marquardt
  Science 320
  (11 April 2008); doi:10.1126/science.1153758

  Abstract

• Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

  Dieter Wicher, Ronny Schäfer, René Bauernfeind, Marcus C. Stensmyr, Regine Heller, Stefan H. Heinemann & Bill S. Hansson
  Nature 452 1007 - 1011
  (13 April 2008); doi:10.1038/nature06861

  Abstract

• Role of IGF Signaling in Olfactory Sensory Map Formation and Axon Guidance

  J Scolnick, K Cui, C Duggan, S Xuan, X Yuan, A Efstratiadis & J Ngai
  Neuron 57
  (27 March 2008); doi:10.1016/j.neuron.2008.01.027

  Abstract

• mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE

  R Cho, J Park, S Wolff, D Xu, C Hopf, J Kim, R Reddy, R Petralia, M Perin & D Linden
  Neuron 57
  (27 March 2008); doi:10.1016/j.neuron.2008.01.010

  Abstract

• Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-κB p50-Deficient Mice

  S. Denis-Donini, A. Dellarole, P. Crociara, M. T. Francese, V. Bortolotto, G. Quadrato, P. L. Canonico, M. Orsetti, P. Ghi, M. Memo, S. A. Bonini, G. Ferrari-Toninelli & M. Grilli
  Journal of Neuroscience 28
  (9 April 2008); doi:10.1523/JNEUROSCI.0148-08.2008

  Abstract

• Postmortem Brain Tissue of Depressed Suicides Reveals Increased Gsα Localization in Lipid Raft Domains Where It Is Less Likely to Activate Adenylyl Cyclase

  R. J. Donati, Y. Dwivedi, R. C. Roberts, R. R. Conley, G. N. Pandey & M. M. Rasenick
  Journal of Neuroscience 28
  (19 March 2008); doi:10.1523/JNEUROSCI.5713-07.2008

  Abstract

• Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

  Y Wen
  Neuron 57
  (13 March 2008); doi:10.1016/j.neuron.2008.02.024

  Abstract

• Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling

  B Ataman
  Neuron 57
  (13 March 2008); doi:10.1016/j.neuron.2008.01.026

  Abstract

• Enhanced Tau Phosphorylation in the Hippocampus of Mice Treated with 3,4-Methylenedioxymethamphetamine ("Ecstasy")

  C. L. Busceti, F. Biagioni, B. Riozzi, G. Battaglia, M. Storto, C. Cinque, G. Molinaro, R. Gradini, A. Caricasole, A. M. Canudas, V. Bruno, F. Nicoletti & F. Fornai
  Journal of Neuroscience 28
  (19 March 2008); doi:10.1523/JNEUROSCI.0159-08.2008

  Abstract

• P2Y₁₂ Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

  K. Kobayashi, H. Yamanaka, T. Fukuoka, Y. Dai, K. Obata & K. Noguchi
  Journal of Neuroscience 28
  (12 March 2008); doi:10.1523/JNEUROSCI.5589-07.2008

  Abstract

• A molecular pathway of neurodegeneration linking -synuclein to ApoE and A peptides

  Gilbert Gallardo, Oliver M Schlüter & Thomas C Südhof
  Nature Neuroscience 11 301 - 308
  (24 February 2008); doi:10.1038/nn2058

  Abstract

• Activation of estrogen receptor- regulates hippocampal synaptic plasticity and improves memory

  Feng Liu, Mark Day, Luis C Muñiz, Daniel Bitran, Robert Arias, Raquel Revilla-Sanchez, Steve Grauer, Guoming Zhang, Cody Kelley, Virginia Pulito, Amy Sung, Ronald F Mervis, Rachel Navarra, Warren D Hirst, Peter H Reinhart, Karen L Marquis, Stephen J Moss, Menelas N Pangalos & Nicholas J Brandon
  Nature Neuroscience 11 334 - 343
  (24 February 2008); doi:10.1038/nn2057

  Abstract

• CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking

  Sharon M Anderson, Katie R Famous, Ghazaleh Sadri-Vakili, Vidhya Kumaresan, Heath D Schmidt, Caroline E Bass, Ernest F Terwilliger, Jang-Ho J Cha & R Christopher Pierce
  Nature Neuroscience 11 344 - 353
  (17 February 2008); doi:10.1038/nn2054

  Abstract

• Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

  May H. Han, Sun-Il Hwang, Dolly B. Roy, Deborah H. Lundgren, Jordan V. Price, Shalina S. Ousman, Guy Haskin Fernald, Bruce Gerlitz, William H. Robinson, Sergio E. Baranzini, Brian W. Grinnell, Cedric S. Raine, Raymond A. Sobel, David K. Han & Lawrence Steinman
  Nature 451 1076 - 1081
  (17 February 2008); doi:10.1038/nature06559

  Abstract

• Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory

  S.-H. Lee, J.-H. Choi, N. Lee, H.-R. Lee, J.-I. Kim, N.-K. Yu, S.-L. Choi, S.-H. Lee, H. Kim & B.-K. Kaang
  Science 319
  (29 February 2008); doi:10.1126/science.1150541

  Abstract

• Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus

  Daniela C. Dieterich, Anna Karpova, Marina Mikhaylova, Irina Zdobnova, Imbritt König, Marco Landwehr, Martin Kreutz, Karl-Heinz Smalla, Karin Richter, Peter Landgraf, Carsten Reissner, Tobias M. Boeckers, Werner Zuschratter, Christina Spilker, Constanze I. Seidenbecher, Craig C. Garner, Eckart D. Gundelfinger & Michael R. Kreutz
  PLoS Biology 6
  (26 Febuary 2008); doi:10.1371/journal.pbio.0060034

  Abstract

• Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus

  H. Yasuda, Y. Huang & T. Tsumoto
  Proceedings of the National Academy of Sciences 105
  (26 February 2008); doi:10.1073/pnas.0708349105

  Abstract

• Nociceptin Receptor Impairs Recognition Memory via Interaction with NMDA Receptor-Dependent Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in the Hippocampus

  C. Goeldner, D. Reiss, J. Wichmann, H. Meziane, B. L. Kieffer & A.-M. Ouagazzal
  Journal of Neuroscience 28
  (27 February 2008); doi:10.1523/JNEUROSCI.3711-07.2008

  Abstract

• A Drosophila model for LRRK2-linked parkinsonism

  Z. Liu, X. Wang, Y. Yu, X. Li, T. Wang, H. Jiang, Q. Ren, Y. Jiao, A. Sawa, T. Moran, C. A. Ross, C. Montell & W. W. Smith
  Proceedings of the National Academy of Sciences 105
  (19 February 2008); doi:10.1073/pnas.0708452105

  Abstract

• Eif-2a Protects Brainstem Motoneurons in a Murine Model of Sleep Apnea

  Y. Zhu, P. Fenik, G. Zhan, B. Sanfillipo-Cohn, N. Naidoo & S. C. Veasey
  Journal of Neuroscience 28
  (27 February 2008); doi:10.1523/JNEUROSCI.5232-07.2008

  Abstract

• Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice

  M Pennuto, E Tinelli, M Malaguti, U Del Carro, M D'Antonio, D Ron, A Quattrini, M Feltri & L Wrabetz
  Neuron 57
  (7 February 2008); doi:10.1016/j.neuron.2007.12.021

  Abstract

• Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

  Vladyslav V Vyazovskiy, Chiara Cirelli, Martha Pfister-Genskow, Ugo Faraguna & Giulio Tononi
  Nature Neuroscience 11 200 - 208
  (20 January 2008); doi:10.1038/nn2035

  Abstract

• Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development

  M. A. Basson, D. Echevarria, C. Petersen Ahn, A. Sudarov, A. L. Joyner, I. J. Mason, S. Martinez & G. R. Martin
  Development 135
  (23 January 2008); doi:10.1242/dev.011569

  Abstract

• Integrin α9β1 is a receptor for nerve growth factor and other neurotrophins

  I. Staniszewska, I. K. Sariyer, S. Lecht, M. C. Brown, E. M. Walsh, G. P. Tuszynski, M. Safak, P. Lazarovici & C. Marcinkiewicz
  Journal of Cell Science 121
  (29 January 2008); doi:10.1242/jcs.000232

  Abstract

• Role of Protein Phosphatase 2A in Regulating the Visual Signaling in Drosophila

  N. Wang, H.-T. Leung, W. L. Pak, Y. T. Carl, B. E. Wadzinski & B.-H. Shieh
  Journal of Neuroscience 28
  (6 February 2008); doi:10.1523/JNEUROSCI.5134-07.2008

  Abstract

• Cysteine-Rich Protein 2, a Novel Downstream Effector of cGMP/cGMP-Dependent Protein Kinase I-Mediated Persistent Inflammatory Pain

  A. Schmidtko, W. Gao, M. Sausbier, I. Rauhmeier, U. Sausbier, E. Niederberger, K. Scholich, A. Huber, W. Neuhuber, H.-D. Allescher, F. Hofmann, I. Tegeder, P. Ruth & G. Geisslinger
  Journal of Neuroscience 28
  (6 February 2008); doi:10.1523/JNEUROSCI.5037-07.2008

  Abstract

• Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network

  O. C. Pertz, Y. Wang, F. Yang, W. Wang, L. J. Gay, M. A. Gristenko, T. R. Clauss, D. J. Anderson, T. Liu, K. J. Auberry, D. G. Camp, R. D. Smith & R. L. Klemke
  Proceedings of the National Academy of Sciences 105
  (12 February 2008); doi:10.1073/pnas.0706545105

  Abstract

• Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor

  Lane Bekar, Witold Libionka, Guo-Feng Tian, Qiwu Xu, Arnulfo Torres, Xiaohai Wang, Ditte Lovatt, Erika Williams, Takahiro Takano, Jurgen Schnermann, Robert Bakos & Maiken Nedergaard
  Nature Medicine 14 75 - 80
  (23 December 2007); doi:10.1038/nm1693

  Abstract

• Genes and (Common) Pathways Underlying Drug Addiction

  Chuan-Yun Li, Xizeng Mao & Liping Wei
  PLoS Computational Biology 4
  (4 January 2008); doi:10.1371/journal.pcbi.0040002

  Abstract

• Ephrin-B reverse signaling promotes structural and functional synaptic maturation in vivo

  Byung Kook Lim, Naoto Matsuda & Mu-ming Poo
  Nature Neuroscience 11 160 - 169
  (13 January 2008); doi:10.1038/nn2033

  Abstract

• Role of GSK3β in behavioral abnormalities induced by serotonin deficiency

  J.-M. Beaulieu, X. Zhang, R. M. Rodriguiz, T. D. Sotnikova, M. J. Cools, W. C. Wetsel, R. R. Gainetdinov & M. G. Caron
  Proceedings of the National Academy of Sciences 105
  (29 January 2008); doi:10.1073/pnas.0711496105

  Abstract

• The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7

  J. R. Gatchel, K. Watase, C. Thaller, J. P. Carson, P. Jafar-Nejad, C. Shaw, T. Zu, H. T. Orr & H. Y. Zoghbi
  Proceedings of the National Academy of Sciences 105
  (29 January 2008); doi:10.1073/pnas.0711257105

  Abstract

• A Mechanism Regulating the Onset of Sox2 Expression in the Embryonic Neural Plate

  Costis Papanayotou, Anne Mey, Anne-Marie Birot, Yasushi Saka, Sharon Boast, Jim C. Smith, Jacques Samarut & Claudio D. Stern
  PLoS Biology 6
  (8 January 2008); doi:10.1371/journal.pbio.0060002

  Abstract

• A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

  J Beaulieu et al.
  Cell 132
  (11 January 2008); doi:10.1016/j.cell.2007.11.041

  Abstract

• Adenosine A_2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

  N Rebola et al.
  Neuron 57
  (10 January 2008); doi:10.1016/j.neuron.2007.11.023

  Abstract

• Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors

  S. Ghosh, T. Marquardt, J. P. Thaler, N. Carter, S. E. Andrews, S. L. Pfaff & T. Hunter
  Proceedings of the National Academy of Sciences 105
  (8 January 2008); doi:10.1073/pnas.0705713105

  Abstract

• The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System

  B. B. Land, M. R. Bruchas, J. C. Lemos, M. Xu, E. J. Melief & C. Chavkin
  Journal of Neuroscience 28
  (9 January 2008); doi:10.1523/JNEUROSCI.4458-07.2008

  Abstract

• Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling

  L. Baki, R. L. Neve, Z. Shao, J. Shioi, A. Georgakopoulos & N. K Robakis
  Journal of Neuroscience 28
  (9 January 2008); doi:10.1523/JNEUROSCI.4067-07.2008

  Abstract

• The Role of Hippocampal GluR1 and GluR2 Receptors in Manic-Like Behavior

  J. Du, T. K. Creson, L.-J. Wu, M. Ren, N. A. Gray, C. Falke, Y. Wei, Y. Wang, R. Blumenthal, R. Machado-Vieira, P. Yuan, G. Chen, M. Zhuo & H. K. Manji
  Journal of Neuroscience 28
  (2 January 2008); doi:10.1523/JNEUROSCI.3080-07.2008

  Abstract