Research library: browse by subject
The Research Library categorizes and alerts you to recent neuroscience- and genomics-related research in journals from the Nature family and from other publishers. Primary research and review articles are included, as are News and Views.
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Disorders of the nervous system
Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
T. Town, Y.Laouar, C. Pittenger, T. Mori, C. A. Szekely, J. Tan, R. S. Duman & R. A. Flavell1
Nature Medicine 14, 681-687
(30 May 2008); doi:10.1038/nm1781Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
Nicolai E Savaskan, Alexandra Heckel, Eric Hahnen, Tobias Engelhorn, Arnd Doerfler, Oliver Ganslandt, Christopher Nimsky, Michael Buchfelder & Ilker Y Eyüpoglu
Nature Medicine
(11 May 2008); doi:10.1038/nm1772Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
T. Walsh, J. M. McClellan, S. E. McCarthy, A. M. Addington, S. B. Pierce, G. M. Cooper, A. S. Nord, M. Kusenda, D. Malhotra, A. Bhandari, S. M. Stray, C. F. Rippey, P. Roccanova, V. Makarov, B. Lakshmi, R. L. Findling, L. Sikich, T. Stromberg, B. Merriman, N. Gogtay, P. Butler, K. Eckstrand, L. Noory, P. Gochman, R. Long, Z. Chen, S. Davis, C. Baker, E. E. Eichler, P. S. Meltzer, S. F. Nelson, A. B. Singleton, M. K. Lee, J. L. Rapoport, M.-C. King & J. Sebat
Science
(27 March 2008); doi:10.1126/science.1155174Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants
P. Cassina, A. Cassina, M. Pehar, R. Castellanos, M. Gandelman, A. Dé Léon, K. M. Robinson, R. P. Mason, J. S. Beckman, L. Barbeito & R. Radi
Journal of Neuroscience 28
(16 April 2008); doi:10.1523/JNEUROSCI.5308-07.2008Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance
T. Bolmont, F. Haiss, D. Eicke, R. Radde, C. A. Mathis, W. E. Klunk, S. Kohsaka, M. Jucker & M. E. Calhoun
Journal of Neuroscience 28
(16 April 2008); doi:10.1523/JNEUROSCI.4814-07.2008Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B. Bowman, Ronald Richman, David E. Hill, Harry T. Orr & Huda Y. Zoghbi
Nature 452 713 - 718
(12 March 2008); doi:10.1038/nature06731A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures
Andrew J Sharp, Heather C Mefford, Kelly Li, Carl Baker, Cindy Skinner, Roger E Stevenson, Richard J Schroer, Francesca Novara, Manuela De gregori, Roberto Ciccone, Adam Broomer, Iris Casuga, Yu Wang, Chunlin Xiao, Catalin Barbacioru, Giorgio Gimelli, Bernardo Dalla Bernardina, Claudia Torniero, Roberto Giorda, Regina Regan, Victoria Murday, Sahar Mansour, Marco Fichera, Lucia Castiglia, Pinella Failla, Mario Ventura, Zhaoshi Jiang, Gregory M Cooper, Samantha J L Knight, Corrado Romano, Orsetta Zuffardi, Caifu Chen, Charles E Schwartz & Evan E Eichler
Nature Genetics 40 322 - 328
(17 February 2008); doi:10.1038/ng.93Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
A. V. Savonenko, T. Melnikova, F. M. Laird, K.-A. Stewart, D. L. Price & P. C. Wong
Proceedings of the National Academy of Sciences 105
(8 April 2008); doi:10.1073/pnas.0710373105Somatostatin Receptor Subtype 4 Couples to the M-Current to Regulate Seizures
C. Qiu, T. Zeyda, B. Johnson, U. Hochgeschwender, L. de Lecea & M. K. Tallent
Journal of Neuroscience 28
(2 April 2008); doi:10.1523/JNEUROSCI.4679-07.2008Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism
S. C. Pandey, R. Ugale, H. Zhang, L. Tang & A. Prakash
Journal of Neuroscience 28
(2 April 2008); doi:10.1523/JNEUROSCI.5731-07.2008Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus
A. Ludányi, L. Erõss, S. Czirják, J. Vajda, P. Halász, M. Watanabe, M. Palkovits, Z. Maglóczky, T. F. Freund & I. Katona
Journal of Neuroscience 28
(19 March 2008); doi:10.1523/JNEUROSCI.4465-07.2008Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
W. S. Liang, E. M. Reiman, J. Valla, T. Dunckley, T. G. Beach, A. Grover, T. L. Niedzielko, L. E. Schneider, D. Mastroeni, R. Caselli, W. Kukull, J. C. Morris, C. M. Hulette, D. Schmechel, J. Rogers & D. A. Stephan
Proceedings of the National Academy of Sciences 105
(18 March 2008); doi:10.1073/pnas.0709259105Postmortem Brain Tissue of Depressed Suicides Reveals Increased Gsα Localization in Lipid Raft Domains Where It Is Less Likely to Activate Adenylyl Cyclase
R. J. Donati, Y. Dwivedi, R. C. Roberts, R. R. Conley, G. N. Pandey & M. M. Rasenick
Journal of Neuroscience 28
(19 March 2008); doi:10.1523/JNEUROSCI.5713-07.2008Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats
M. M. C. Gonzalez & G. Aston-jones
Proceedings of the National Academy of Sciences 105
(25 March 2008); doi:10.1073/pnas.0703615105Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing
Y Wen
Neuron 57
(13 March 2008); doi:10.1016/j.neuron.2008.02.024C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging
Tjakko J. van Ham, Karen L. Thijssen, Rainer Breitling, Robert M. W. Hofstra, Ronald H. A. Plasterk, Ellen A. A. Nollen & Stuart K. Kim
PLoS Genetics 4
(21 March 2008); doi:10.1371/journal.pgen.1000027SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
Rea Biacsi, Daman Kumari, Karen Usdin & Harry Orr
PLoS Genetics 4
(14 March 2008); doi:10.1371/journal.pgen.1000017Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning
C. R. Tessier & K. Broadie
Development 135
(15 April 2008); doi:10.1242/dev.015867Loss of Astrocytic Domain Organization in the Epileptic Brain
N. A. Oberheim, G.-F. Tian, X. Han, W. Peng, T. Takano, B. Ransom & M. Nedergaard
Journal of Neuroscience 28
(26 March 2008); doi:10.1523/JNEUROSCI.4980-07.2008Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes
S.-Y. Chou, J.-Y. Weng, H.-L. Lai, F. Liao, S. H. Sun, P.-H. Tu, D. W. Dickson & Y. Chern
Journal of Neuroscience 28
(26 March 2008); doi:10.1523/JNEUROSCI.0116-08.2008A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury
J. P. de Rivero Vaccari, G. Lotocki, A. E. Marcillo, W. D. Dietrich & R. W. Keane
Journal of Neuroscience 28
(26 March 2008); doi:10.1523/JNEUROSCI.0157-08.2008ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
Zhihui Zhong, Rashid Deane, Zarina Ali, Margaret Parisi, Yuriy Shapovalov, M Kerry O'banion, Konstantin Stojanovic, Abhay Sagare, Severine Boillee, Don W Cleveland & Berislav V Zlokovic
Nature Neuroscience 11 420 - 422
(16 March 2008); doi:10.1038/nn2073Neurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism
D. T. George, J. Gilman, J. Hersh, A. Thorsell, D. Herion, C. Geyer, X. Peng, W. Kielbasa, R. Rawlings, J. E. Brandt, D. R. Gehlert, J. T. Tauscher, S. P. Hunt, D. Hommer & M. Heilig
Science 319
(14 March 2008); doi:10.1126/science.1153813-
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
J. Sreedharan, I. P. Blair, V. B. Tripathi, X. Hu, C. Vance, B. Rogelj, S. Ackerley, J. C. Durnall, K. L. Williams, E. Buratti, F. Baralle, J. de Belleroche, J. D. Mitchell, P. N. Leigh, A. Al-Chalabi, C. C. Miller, G. Nicholson & C. E. Shaw
Science
(28 February 2008); doi:10.1126/science.1154584 -
A molecular pathway of neurodegeneration linking
-synuclein to ApoE and A
peptidesGilbert Gallardo, Oliver M Schlüter & Thomas C Südhof
Nature Neuroscience 11 301 - 308
(24 February 2008); doi:10.1038/nn2058 -
Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease
E. P. Meyer, A. Ulmann-Schuler, M. Staufenbiel & T. Krucker
Proceedings of the National Academy of Sciences 105
(25 February 2008); doi:10.1073/pnas.0709788105 -
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
A. Buffo, I. Rite, P. Tripathi, A. Lepier, D. Colak, A.-P. Horn, T. Mori & M. Götz
Proceedings of the National Academy of Sciences 105
(25 February 2008); doi:10.1073/pnas.0709002105 -
The Mitochondrial Protease AFG3L2 Is Essential for Axonal Development
F. Maltecca, A. Aghaie, D. G. Schroeder, L. Cassina, B. A. Taylor, S. J. Phillips, M. Malaguti, S. Previtali, J.-L. Guénet, A. Quattrini, G. A. Cox & G. Casari
Journal of Neuroscience 28
(12 March 2008); doi:10.1523/JNEUROSCI.4677-07.2008 -
Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus
H. P. Goodkin, S. Joshi, Z. Mtchedlishvili, J. Brar & J. Kapur
Journal of Neuroscience 28
(5 March 2008); doi:10.1523/JNEUROSCI.3426-07.2008 -
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
Alexis M Stranahan, Thiruma V Arumugam, Roy G Cutler, Kim Lee, Josephine M Egan & Mark P Mattson
Nature Neuroscience 11 309 - 317
(17 February 2008); doi:10.1038/nn2055 -
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
May H. Han, Sun-Il Hwang, Dolly B. Roy, Deborah H. Lundgren, Jordan V. Price, Shalina S. Ousman, Guy Haskin Fernald, Bruce Gerlitz, William H. Robinson, Sergio E. Baranzini, Brian W. Grinnell, Cedric S. Raine, Raymond A. Sobel, David K. Han & Lawrence Steinman
Nature 451 1076 - 1081
(17 February 2008); doi:10.1038/nature06559 -
Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1
A. Y. Hung, K. Futai, C. Sala, J. G. Valtschanoff, J. Ryu, M. A. Woodworth, F. L. Kidd, C. C. Sung, T. Miyakawa, M. F. Bear, R. J. Weinberg & M. Sheng
Journal of Neuroscience 28
(13 February 2008); doi:10.1523/jneurosci.3032-07.2008 -
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Koji Yamanaka, Seung Joo Chun, Severine Boillee, Noriko Fujimori-Tonou, Hirofumi Yamashita, David H Gutmann, Ryosuke Takahashi, Hidemi Misawa & Don W Cleveland
Nature Neuroscience 11 251 - 253
(3 February 2008); doi:10.1038/nn2047 -
Alleviation of A
-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse modelD Takeuchi, N Sato, M Shimamura, H Kurinami, S Takeda, M Shinohara, S Suzuki, M Kojima, T Ogihara & R Morishita
Gene Therapy
(21 February 2008); doi:10.1038/sj.gt.3303094 -
Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking
F. M. Laird, M. H. Farah, S. Ackerley, A. Hoke, N. Maragakis, J. D. Rothstein, J. Griffin, D. L. Price, L. J. Martin & P. C. Wong
Journal of Neuroscience 28
(27 February 2008); doi:10.1523/JNEUROSCI.4231-07.2008 -
An Aggregate-Inducing Peripherin Isoform Generated through Intron Retention Is Upregulated in Amyotrophic Lateral Sclerosis and Associated with Disease Pathology
S. Xiao, S. Tjostheim, T. Sanelli, J. R. McLean, P. Horne, Y. Fan, J. Ravits, M. J. Strong & J. Robertson
Journal of Neuroscience 28
(20 February 2008); doi:10.1523/JNEUROSCI.3222-07.2008 -
Systemic Vesicular Stomatitis Virus Selectively Destroys Multifocal Glioma and Metastatic Carcinoma in Brain
K. Özduman, G. Wollmann, J. M. Piepmeier & A. N. van den Pol
Journal of Neuroscience 28
(20 February 2008); doi:10.1523/JNEUROSCI.4905-07.2008 -
A Drosophila model for LRRK2-linked parkinsonism
Z. Liu, X. Wang, Y. Yu, X. Li, T. Wang, H. Jiang, Q. Ren, Y. Jiao, A. Sawa, T. Moran, C. A. Ross, C. Montell & W. W. Smith
Proceedings of the National Academy of Sciences 105
(19 February 2008); doi:10.1073/pnas.0708452105 -
Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia
J. M. Solowska, G. Morfini, A. Falnikar, B. T. Himes, S. T. Brady, D. Huang & P. W. Baas
Journal of Neuroscience 28
(27 February 2008); doi:10.1523/JNEUROSCI.3159-07.2008 -
Eif-2a Protects Brainstem Motoneurons in a Murine Model of Sleep Apnea
Y. Zhu, P. Fenik, G. Zhan, B. Sanfillipo-Cohn, N. Naidoo & S. C. Veasey
Journal of Neuroscience 28
(27 February 2008); doi:10.1523/JNEUROSCI.5232-07.2008 -
Lithium delays progression of amyotrophic lateral sclerosis
F. Fornai, P. Longone, L. Cafaro, O. Kastsiuchenka, M. Ferrucci, M. L. Manca, G. Lazzeri, A. Spalloni, N. Bellio, P. Lenzi, N. Modugno, G. Siciliano, C. Isidoro, L. Murri, S. Ruggieri & A. Paparelli
Proceedings of the National Academy of Sciences 105
(12 February 2008); doi:10.1073/pnas.0708022105 -
Rapid appearance and local toxicity of amyloid-
plaques in a mouse model of Alzheimer's diseaseMelanie Meyer-Luehmann, Tara L. Spires-Jones, Claudia Prada, Monica Garcia-Alloza, Alix de Calignon, Anete Rozkalne, Jessica Koenigsknecht-Talboo, David M. Holtzman, Brian J. Bacskai & Bradley T. Hyman
Nature 451 720 - 724
doi:10.1038/nature06616 -
Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice
M Pennuto, E Tinelli, M Malaguti, U Del Carro, M D'Antonio, D Ron, A Quattrini, M Feltri & L Wrabetz
Neuron 57
(7 February 2008); doi:10.1016/j.neuron.2007.12.021 -
A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging
J. A. Miller, M. C. Oldham & D. H. Geschwind
Journal of Neuroscience 28
(6 February 2008); doi:10.1523/JNEUROSCI.4098-07.2008 -
Polyglutamine Genes Interact to Modulate the Severity and Progression of Neurodegeneration in Drosophila
Derek Lessing & Nancy M. Bonini
PLoS Biology 6
(12 February 2008); doi:10.1371/journal.pbio.0060029 -
The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels
C. F. Barrett & R. W. Tsien
Proceedings of the National Academy of Sciences 105
(12 February 2008); doi:10.1073/pnas.0710501105 -
Necdin Plays a Role in the Serotonergic Modulation of the Mouse Respiratory Network: Implication for Prader-Willi Syndrome
S. Zanella, F. Watrin, S. Mebarek, F. Marly, M. Roussel, C. Gire, G. Diene, M. Tauber, F. Muscatelli & G. Hilaire
Journal of Neuroscience 28
(13 February 2008); doi:10.1523/JNEUROSCI.4334-07.2008 -
Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor
Lane Bekar, Witold Libionka, Guo-Feng Tian, Qiwu Xu, Arnulfo Torres, Xiaohai Wang, Ditte Lovatt, Erika Williams, Takahiro Takano, Jurgen Schnermann, Robert Bakos & Maiken Nedergaard
Nature Medicine 14 75 - 80
(23 December 2007); doi:10.1038/nm1693 -
The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7
J. R. Gatchel, K. Watase, C. Thaller, J. P. Carson, P. Jafar-Nejad, C. Shaw, T. Zu, H. T. Orr & H. Y. Zoghbi
Proceedings of the National Academy of Sciences 105
(29 January 2008); doi:10.1073/pnas.0711257105 -
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1
W.-X. Wang, B. W. Rajeev, A. J. Stromberg, N. Ren, G. Tang, Q. Huang, I. Rigoutsos & P. T. Nelson
Journal of Neuroscience 28
(30 January 2008); doi:10.1523/JNEUROSCI.5065-07.2008 -
Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm
E Romero et al.
Neuron 57
(10 January 2008); doi:10.1016/j.neuron.2007.11.025 -
CNS Delivery of Vectored Prion-specific Single-chain Antibodies Delays Disease Onset
Charles A Wuertzer, Mark A Sullivan, Xing Qiu & Howard J Federoff
Molecular Therapy
(8 January 2008); doi:10.1038/sj.mt.6300387 -
Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice
L. Chen, Y. Ding, B. Cagniard, A. D. Van Laar, A. Mortimer, W. Chi, T. G. Hastings, U. J. Kang & X. Zhuang
Journal of Neuroscience 28
(9 January 2008); doi:10.1523/JNEUROSCI.3602-07.2008 -
Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling
L. Baki, R. L. Neve, Z. Shao, J. Shioi, A. Georgakopoulos & N. K Robakis
Journal of Neuroscience 28
(9 January 2008); doi:10.1523/JNEUROSCI.4067-07.2008 -
Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease
K. Trinh, K. Moore, P. D. Wes, P. J. Muchowski, J. Dey, L. Andrews & L. J. Pallanck
Journal of Neuroscience 28
(9 January 2008); doi:10.1523/JNEUROSCI.4778-07.2008 -
Association between Microdeletion and Microduplication at 16p11.2 and Autism
L. A. Weiss, Y. Shen, J. M. Korn, D. E. Arking, D. T. Miller, R. Fossdal, E. Saemundsen, H. Stefansson, M. A.R. Ferreira, T. Green, O. S. Platt, D. M. Ruderfer, C. A. Walsh, D. Altshuler, A. Chakravarti, R. E. Tanzi, K. Stefansson, S. L. Santangelo, J. F. Gusella, P. Sklar, B.-L. Wu & M. J. Daly
New England Journal of Medicine
(9 January 2008); doi:10.1056/nejmoa075974 -
Correction of Fragile X Syndrome in Mice
G Dolen et al.
Neuron 56 955 - 962
(20 December 2007); doi:10.1016/j.neuron.2007.12.001 -
dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1
Ismael Al-Ramahi, Alma M. Pérez, Janghoo Lim, Minghang Zhang, Rie Sorensen, Maria de Haro, Joana Branco, Stefan M. Pulst, Huda Y. Zoghbi & Juan Botas
PLoS Genetics 3
(28 December 2007); doi:10.1371/journal.pgen.0030234 -
Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD
J. Wu, Md. R. Basha, B. Brock, D. P. Cox, F. Cardozo-Pelaez, C. A. McPherson, J. Harry, D. C. Rice, B. Maloney, D. Chen, D. K. Lahiri & N. H. Zawia
Journal of Neuroscience 28
(2 January 2008); doi:10.1523/JNEUROSCI.4405-07.2008 -
Ubiquitin Proteasome-Mediated Synaptic Reorganization: A Novel Mechanism Underlying Rapid Ischemic Tolerance
R. Meller, S. J. Thompson, T. A. Lusardi, A. N. Ordonez, M. D. Ashley, V. Jessick, W. Wang, D. J. Torrey, D. C. Henshall, P. R. Gafken, J. A. Saugstad, Z.-G. Xiong & R. P. Simon
Journal of Neuroscience 28
(2 January 2008); doi:10.1523/JNEUROSCI.3474-07.2008 -
A Critical Function for β-Amyloid Precursor Protein in Neuronal Migration Revealed by In Utero RNA Interference
T. L. Young-Pearse, J. Bai, R. Chang, J. B. Zheng, J. J. LoTurco & D. J. Selkoe
Journal of Neuroscience 27
(26 December 2007); doi:10.1523/JNEUROSCI.4701-07.2007
