Drug discovery

• ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

  Ryu, H. et al.
  PNAS 103 19176-19181
  (1 December 2006); doi:10.1073/pnas.0606373103

  Abstract

• GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide

  Wahle, T. et al.
  The Journal of Neuroscience 26 12838-12846
  doi:10.1523/JNEUROSCI.1982-06.2006

  Abstract

• Retinal repair by transplantation of photoreceptor precursors

  R. E. MacLaren, R. A. Pearson, A. MacNeil, R. H. Douglas, T. E. Salt, M. Akimoto, A. Swaroop, J. C. Sowden and R. R. Ali
  Nature 444 203 - 207
  doi:10.1038/nature05161

  Abstract

• Identification of nesfatin-1 as a satiety molecule in the hypothalamus

  Shinsuke Oh-I, Hiroyuki Shimizu, Tetsurou Satoh, Shuichi Okada, Sachika Adachi, Kinji Inoue, Hiroshi Eguchi, Masanori Yamamoto, Toshihiro Imaki, Koushi Hashimoto, Takafumi Tsuchiya, Tsuyoshi Monden, Kazuhiko Horiguchi, Masanobu Yamada and Masatomo Mori
  Nature 443 709 - 712
  (1 October 2006); doi:10.1038/nature05162

  Abstract

• Cell death in the nervous system

  Dale E. Bredesen, Rammohan V. Rao and Patrick Mehlen
  Nature 443 796 - 802
  (18 October 2006); doi:10.1038/nature05293

  Abstract

• 100 Years and Counting: Prospects for Defeating Alzheimer's Disease

  Roberson, E. D. & Mucke, L.
  Science 314
  (03 November 2006); doi:10.1126/science.1132813

  Abstract

• Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage

  Tong Cheng, Anthony L Petraglia, Zhang Li, Meenakshisundaram Thiyagarajan, Zhihui Zhong, Zhenhua Wu, Dong Liu, Sanjay B Maggirwar, Rashid Deane, José A Fernández, Barbra LaRue, John H Griffin, Michael Chopp and Berislav V Zlokovic
  Nature Medicine 12 1278 - 1285
  (29 October 2006); doi:10.1038/nm1498

  Abstract

• μO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

  Ekberg, J. et al.
  Proceedings of the National Academy of Sciences 103
  (31 October 2006); doi:10.1073/pnas.0601819103

  Abstract

• Identification of nesfatin-1 as a satiety molecule in the hypothalamus

  Shinsuke Oh-I, Hiroyuki Shimizu, Tetsurou Satoh, Shuichi Okada, Sachika Adachi, Kinji Inoue, Hiroshi Eguchi, Masanori Yamamoto, Toshihiro Imaki, Koushi Hashimoto, Takafumi Tsuchiya, Tsuyoshi Monden, Kazuhiko Horiguchi, Masanobu Yamada and Masatomo Mori
  Nature 443 709 - 712
  (1 October 2006); doi:10.1038/nature05162

  Abstract

• Cell death in the nervous system

  Dale E. Bredesen, Rammohan V. Rao and Patrick Mehlen
  Nature 443 796 - 802
  (18 October 2006); doi:10.1038/nature05293

  Abstract

• An Inhibitor of Serine Proteases, Neuroserpin, Acts as a Neuroprotective Agent in a Mouse Model of Neurodegenerative Disease

  Simonin, Y., Charron, Y., Sonderegger, P., Vassalli, J. & Kato, A. C.
  Journal of Neuroscience
  (11 October 2006); doi:10.1523/JNEUROSCI.3582-06.2006

  Abstract

• Bombesin Receptors as a Novel Anti-Anxiety Therapeutic Target: BB1 Receptor Actions on Anxiety through Alterations of Serotonin Activity

  Merali, Z. et al.
  Journal of Neuroscience
  (11 October 2006); doi:10.1523/JNEUROSCI.1219-06.2006

  Abstract

• Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann-Pick C disease

  Langmade, S. J. et al.
  Proceedings of the National Academy of Sciences 103
  (29 August 2006); doi:10.1073/pnas.0606218103

  Abstract

• Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

  Yoshimoto, R. et al.
  Proceedings of the National Academy of Sciences 103
  (5 September 2006); doi:10.1073/pnas.0506104103

  Abstract

• TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity

  Bartologmucci, A. et al.
  Proceedings of the National Academy of Sciences 103
  (18 September 2006); doi:10.1073/pnas.0606102103

  Abstract

• From the Cover: Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

  Wang, D. et al.
  Proceedings of the National Academy of Sciences 103
  (24 August 2006); doi:10.1073/pnas.0604661103

  Abstract

• Molecular biology of amyotrophic lateral sclerosis: insights from genetics

  Piera Pasinelli and Robert H. Brown
  Nature Reviews Neuroscience 7 710 - 723
  doi:10.1038/nrn1971

  Abstract

• Dynamic regulation of Drosophila nuclear receptor activity in vivo

  Palanker, L. et al.
  Development 133
  (16 August 2006); doi:10.1242/dev.02512

  Abstract

• rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice

  Paul Gregorevic, James M Allen, Elina Minami, Michael J Blankinship, Miki Haraguchi, Leonard Meuse, Eric Finn, Marvin E Adams, Stanley C Froehner, Charles E Murry and Jeffrey S Chamberlain
  Nature Medicine 12 787 - 789
  (2 July 2006); doi:10.1038/nm1439

  Abstract