Drug discovery

• The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex

  J. F. M. Vetencourt, A. Sale, A. Viegi, L. Baroncelli, R. De Pasquale, O. F. O'Leary, E. Castren & L. Maffei
  Science 320
  (18 April 2008); doi:10.1126/science.1150516

  Abstract

• SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

  Rea Biacsi, Daman Kumari, Karen Usdin & Harry Orr
  PLoS Genetics 4
  (14 March 2008); doi:10.1371/journal.pgen.1000017

  Abstract

• Neurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism

  D. T. George, J. Gilman, J. Hersh, A. Thorsell, D. Herion, C. Geyer, X. Peng, W. Kielbasa, R. Rawlings, J. E. Brandt, D. R. Gehlert, J. T. Tauscher, S. P. Hunt, D. Hommer & M. Heilig
  Science 319
  (14 March 2008); doi:10.1126/science.1153813

  Abstract

• Pharmacological disruption of calcium channel trafficking by the α2δ ligand gabapentin

  J. Hendrich, A. T. Van Minh, F. Heblich, M. Nieto-Rostro, K. Watschinger, J. Striessnig, J. Wratten, A. Davies & A. C. Dolphin
  Proceedings of the National Academy of Sciences 105
  (25 February 2008); doi:10.1073/pnas.0708930105

  Abstract

• Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

  May H. Han, Sun-Il Hwang, Dolly B. Roy, Deborah H. Lundgren, Jordan V. Price, Shalina S. Ousman, Guy Haskin Fernald, Bruce Gerlitz, William H. Robinson, Sergio E. Baranzini, Brian W. Grinnell, Cedric S. Raine, Raymond A. Sobel, David K. Han & Lawrence Steinman
  Nature 451 1076 - 1081
  (17 February 2008); doi:10.1038/nature06559

  Abstract

• Systemic Vesicular Stomatitis Virus Selectively Destroys Multifocal Glioma and Metastatic Carcinoma in Brain

  K. Özduman, G. Wollmann, J. M. Piepmeier & A. N. van den Pol
  Journal of Neuroscience 28
  (20 February 2008); doi:10.1523/JNEUROSCI.4905-07.2008

  Abstract

• Lithium delays progression of amyotrophic lateral sclerosis

  F. Fornai, P. Longone, L. Cafaro, O. Kastsiuchenka, M. Ferrucci, M. L. Manca, G. Lazzeri, A. Spalloni, N. Bellio, P. Lenzi, N. Modugno, G. Siciliano, C. Isidoro, L. Murri, S. Ruggieri & A. Paparelli
  Proceedings of the National Academy of Sciences 105
  (12 February 2008); doi:10.1073/pnas.0708022105

  Abstract

• Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells

  J.-W. Wang, D. J. David, J. E. Monckton, F. Battaglia & R. Hen
  Journal of Neuroscience 28
  (6 February 2008); doi:10.1523/JNEUROSCI.3632-07.2008

  Abstract

• Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression

  M Uhr, A Tontsch, C Namendorf, S Ripke, S Lucae, M Ising, T Dose, M Ebinger, M Rosenhagen & M Kohli
  Neuron 57
  (24 January 2008); doi:10.1016/j.neuron.2007.11.017

  Abstract

• Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor

  Lane Bekar, Witold Libionka, Guo-Feng Tian, Qiwu Xu, Arnulfo Torres, Xiaohai Wang, Ditte Lovatt, Erika Williams, Takahiro Takano, Jurgen Schnermann, Robert Bakos & Maiken Nedergaard
  Nature Medicine 14 75 - 80
  (23 December 2007); doi:10.1038/nm1693

  Abstract

• Reversal of pathological pain through specific spinal GABA_A receptor subtypes

  Julia Knabl, Robert Witschi, Katharina Hösl, Heiko Reinold, Ulrike B. Zeilhofer, Seifollah Ahmadi, Johannes Brockhaus, Marina Sergejeva, Andreas Hess, Kay Brune, Jean-Marc Fritschy, Uwe Rudolph, Hanns Möhler & Hanns Ulrich Zeilhofer
  Nature 451 330 - 334
  doi:10.1038/nature06493

  Abstract

• CNS Delivery of Vectored Prion-specific Single-chain Antibodies Delays Disease Onset

  Charles A Wuertzer, Mark A Sullivan, Xing Qiu & Howard J Federoff
  Molecular Therapy
  (8 January 2008); doi:10.1038/sj.mt.6300387

  Abstract

• Targeting Axon Growth from Neuronal Transplants along Preformed Guidance Pathways in the Adult CNS

  K. S. Ziemba, N. Chaudhry, A. G. Rabchevsky, Y. Jin & G. M. Smith
  Journal of Neuroscience 28
  (9 January 2008); doi:10.1523/JNEUROSCI.3819-07.2008

  Abstract

• Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease

  K. Trinh, K. Moore, P. D. Wes, P. J. Muchowski, J. Dey, L. Andrews & L. J. Pallanck
  Journal of Neuroscience 28
  (9 January 2008); doi:10.1523/JNEUROSCI.4778-07.2008

  Abstract

• Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates

  S. A. Deadwyler, L. Porrino, J. M. Siegel & R. E. Hampson
  Journal of Neuroscience 27
  (26 December 2007); doi:10.1523/JNEUROSCI.3878-07.2007

  Abstract